cis Element/Transcription Factor Analysis (cis/TF): A Method for Discovering Transcription Factor/cis Element Relationships

A Regular Indirect Boundary Element Method for Thermal Analysis

A Regular Indirect Boundary Element Method for Thermal Analysis

Novel Cis Element for Tissue-Specific Transcription of Rat Platelet-Derived Growth Factor b-Receptor Gene

Platelet-derived growth factor (PDGF) and its receptors are widely expressed in several tissues in the stage of cellular growth and development. In adulthood, PDGF b-receptor (PDGFbR) is mainly detected in pathological conditions such as atherosclerotic lesions and injured vascular wall. The purpose of the present study was to elucidate the underlying mechanism of PDGFbR gene expression under p...

Novel cis element for tissue-specific transcription of rat platelet-derived growth factor beta-receptor gene.

Platelet-derived growth factor (PDGF) and its receptors are widely expressed in several tissues in the stage of cellular growth and development. In adulthood, PDGF beta-receptor (PDGFbetaR) is mainly detected in pathological conditions such as atherosclerotic lesions and injured vascular wall. The purpose of the present study was to elucidate the underlying mechanism of PDGFbetaR gene expressio...

ANN-Spec: a method for discovering transcription factor binding sites with improved specificity.

This work describes ANN-Spec, a machine learning algorithm and its application to discovering un-gapped patterns in DNA sequence. The approach makes use of an Artificial Neural Network and a Gibbs sampling method to define the Specificity of a DNA-binding protein. ANN-Spec searches for the parameters of a simple network (or weight matrix) that will maximize the specificity for binding sequences...